The historic Wheeler-Knight House is an abandoned residence along the National Pike in Centerville, Pennsylvania.
Jonathan Knight purchased 173 acres in what is now Centerville Borough in Fayette County on March 29, 1839. Knight had served as a land surveyor and civil engineer, before entering politics in both houses of the state legislature and as a member of the United States Congress. Knight was also the Commissioner on the National Pike in the 1820s and was responsible for the layout of Beallsville and Scenery Hill. Knightstown, Indiana was named in his honor.
The house was later owned by Oliver Taylor, William Pepper, and S. Coletti.